By
Rebecca Seales
Last updated at 2:01 AM on 6th March 2012
A drug that could ‘stop arthritis in its tracks’ is being tested in a British laboratory.
In ‘very exciting’ but early-stage tests, the drug prevented the inflammation responsible for the pain, swelling and stiffness of rheumatoid arthritis.
Much more work is needed but the research could lead to an effective and inexpensive way of treating the condition that affects 350,000 Britons.
An arthritic hand: This coloured X-ray shows joint damage caused by severe rheumatoid arthritis. As the cartilage is worn away, new bone grows as part of the repair process, causing stiffness and deformity of the fingers
The disease causes chronic pain and inflammation in affected joints, and is triggered when elements of the immune system attack the body.
White blood cells known as T-cells are integral to the process.
Study leader Dr Graeme O’Boyle, from the University of Newcastle, said of the research development:
‘Imagine that the damaged joint is covered in flags which are signalling to the white blood cells.
‘Traditional treatments have involved pulling down the flags one by one, but what we have done is use an agent which in effect ‘blindfolds’ the white blood cells.
‘Therefore, they don’t know which way to travel and so won’t add to the damage.’
The research was funded by the charity Arthritis Research UK, and published in the journal Proceedings of the National Academy of Sciences.
Using tests on a genetically engineered mouse with a human-like immune system, the team discovered that a compound called PS372424 blocked the ability of T-cells to invade joints.
A possible cure? Professor Alan Silman, medical director of Arthritis Research UK, said the research was in its early stages but described it as ‘very exciting’
Only the white blood cells implicated in rheumatoid arthritis are affected, meaning there is no wider suppressant effect on the body’s immune system.
Professor Alan Silman, medical director of Arthritis Research UK, said: ‘Although modern treatments have changed the outcome for many patients with rheumatoid arthritis, firstly not all patients respond to them and secondly, even in those patients who do respond in some way, we can’t completely get rid of the inflammation that damages their joints.
‘This research is very exciting, as although it is in its early stages, if it can be transferred to humans it could shut down the inflammation that causes rheumatoid arthritis.’
Work will now be conducted to improve the drug-like properties of PS372424 with a view to preparing it for clinical trials.
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As a sufferer of severe RA and associated complications for the last 18 years, any new research into Rheumatoid Disease is welcomed. For some people, myself included, RA is not just a disease of the joints, it affects the eyes,(Sjogren’s syndrome) blood vessels, lungs and other soft tissue as well. I have tried many drugs throughout the years but have suffered adverse effects and had to stop the treatments. All my joints are affected, and I am now at stage 4. As side effects of some treatments can cause other serious illnesses, sufferers have a lot to consider. Maybe targeted treatment is the way forward, but I would like to see more research into why the immune system turns on sufferers in the first place. I believe the way we handle stress has something to do with it.
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Even if NIET supports it will the PCTs or whatever they are called by then pay for it?
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DM ‘science’ journalists favourite word – ‘could’. The trouble with stories like this about very early research is that it gets suffering people’s hopes up beyond the possibility of delivery which maybe decades away, if at all. So many things that journalists’ sensationalist stories, call ‘breakthroughs’ are nothing of the sort and most people do not realise that the vast number of these things are found in later trials to be false dawns. Occasionally there are genuine breakthroughs – but these are only one in thousands of trials that prove good enough to get the whole way as medicines.
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Sounds good but sufferers should google diet and RA as eliminating certain foods does make a difference. Dr. Gail Darlington, an English rheumatologist has written a book on the subject. Avoiding acidic foods e.g. tomatoes, dairy and red meat does help.
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I always thought Rheumatoid Arthritis was just aches and pains – until I got it myself – totally out of the blue -aged 39.
It is agonising, and doctors do not know what causes it or what to do about it. It would be great if something could be found without horrendous side effects. I take nothing for mine and I keep working, but my life is a tenth of what it was.
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I really hope this is the drug that many Arthritis sufferers have waited for. My Mum suffers from chronic RA and it can be heartbreaking to see her in so much pain. She’s only 57 and has suffered since she was 21.
I still feel that there are people that dismiss arthritis as something ‘old people’ suffer from but nothing could be further from the truth.
She’s tried many different drugs over the years and unfortunately the only one that really gave her a new lease of life and a life free from pain was damaging her liver, so now she’s self injecting a relatively new drug once a week but still has days when she struggles to walk or even make a cup of tea. Her hands, feet and knees look like a 90 year olds, I’d do anything to take her pain away.
I pray with all my heart that this drug is the wonder drug that sufferers have waited too long for.
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Google these, cayenne, ground chilli, these two can help cut out the pain of Arthritis, this I knoiw as I’m on cayenne and the pain has gone from my righthand knuckle joints this year, as they give me a real pain during hand olive picking and take about six weeks to get over it.
Also if you get on earthclinic they say about high doses of glucosamine is a cure for arthritis.
Ok I dont know how this works with any drugs people are on, or how this works with RA, but sometimes its the simple things that work the best.
Good Luck
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My Mother suffers badly from RA.Her hands were badly swollen and I rubbed on some Penang Nutmeg oil.We had recently been to Malaysia and bought some after being assured it helped all sorts of conditions.We didn’t believe it but were on holiday so bought it.It worked!Next morning all swelling was down and her hands felt much better.She now uses it every day and has had no swelling for 2 months.You can buy Nutmeg oil on the net but it is not Penang Nutmeg oil.We are aiming to return next year and will buy loads!
By the way,I then used it on my neck and it worked for me too.
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Works on mice ! Great !
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There are already drugs available that work in this way such as Humira which my mother took for RA. It acts by suppressing the immune system and despite being screened for latent TB before starting the drug she was dead within 3 months from full blown tuberculosis.
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Article source: http://www.dailymail.co.uk/health/article-2110490/Drug-treat-arthritis-stopping-immune-attacking-joints.html?ITO=1490












