Your Arthritis dot org

Helping you and your arthritis

By
Rebecca Seales

Last updated at 2:01 AM on 6th March 2012

A drug that could ‘stop arthritis in its tracks’ is being tested in a British laboratory.

In ‘very exciting’ but early-stage tests, the drug prevented the inflammation responsible for the pain, swelling and stiffness of rheumatoid arthritis.

Much more work is needed but the research could lead to an effective and inexpensive way of treating the condition that affects 350,000 Britons.

An arthritic hand: This coloured X-ray shows joint damage caused by severe rheumatoid arthritis. As the cartilage is worn away, new bone grows as part of the repair process, causing stiffness and deformity of the fingers

An arthritic hand: This coloured X-ray shows joint damage caused by severe rheumatoid arthritis. As the cartilage is worn away, new bone grows as part of the repair process, causing stiffness and deformity of the fingers

The disease causes chronic pain and inflammation in affected joints, and is triggered when elements of the immune system attack the body. 

White blood cells known as T-cells are integral to the process.

Study leader Dr Graeme O’Boyle, from the University of Newcastle, said of the research development:

‘Imagine that the damaged joint is covered in flags which are signalling to the white blood cells.

‘Traditional treatments have involved pulling down the flags one by one, but what we have done is use an agent which in effect ‘blindfolds’ the white blood cells.

‘Therefore, they don’t know which way to travel and so won’t add to the damage.’

The research was funded by the charity Arthritis Research UK, and published in the journal Proceedings of the National Academy of Sciences.

Using tests on a genetically engineered mouse with a human-like immune system, the team discovered that a compound called PS372424 blocked the ability of T-cells to invade joints.

A possible cure? Professor Alan Silman, medical director of Arthritis Research UK, said the research was in its early stages but described it as 'very exciting'

A possible cure? Professor Alan Silman, medical director of Arthritis Research UK, said the research was in its early stages but described it as ‘very exciting’

Only the white blood cells implicated in rheumatoid arthritis are affected, meaning there is no wider suppressant effect on the body’s immune system.

Professor Alan Silman, medical director of Arthritis Research UK, said: ‘Although modern treatments have changed the outcome for many patients with rheumatoid arthritis, firstly not all patients respond to them and secondly, even in those patients who do respond in some way, we can’t completely get rid of the inflammation that damages their joints.

‘This research is very exciting, as although it is in its early stages, if it can be transferred to humans it could shut down the inflammation that causes rheumatoid arthritis.’

Work will now be conducted to improve the drug-like properties of PS372424 with a view to preparing it for clinical trials.

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As a sufferer of severe RA and associated complications for the last 18 years, any new research into Rheumatoid Disease is welcomed. For some people, myself included, RA is not just a disease of the joints, it affects the eyes,(Sjogren’s syndrome) blood vessels, lungs and other soft tissue as well. I have tried many drugs throughout the years but have suffered adverse effects and had to stop the treatments. All my joints are affected, and I am now at stage 4. As side effects of some treatments can cause other serious illnesses, sufferers have a lot to consider. Maybe targeted treatment is the way forward, but I would like to see more research into why the immune system turns on sufferers in the first place. I believe the way we handle stress has something to do with it.

Even if NIET supports it will the PCTs or whatever they are called by then pay for it?

DM ‘science’ journalists favourite word – ‘could’. The trouble with stories like this about very early research is that it gets suffering people’s hopes up beyond the possibility of delivery which maybe decades away, if at all. So many things that journalists’ sensationalist stories, call ‘breakthroughs’ are nothing of the sort and most people do not realise that the vast number of these things are found in later trials to be false dawns. Occasionally there are genuine breakthroughs – but these are only one in thousands of trials that prove good enough to get the whole way as medicines.

Sounds good but sufferers should google diet and RA as eliminating certain foods does make a difference. Dr. Gail Darlington, an English rheumatologist has written a book on the subject. Avoiding acidic foods e.g. tomatoes, dairy and red meat does help.

I always thought Rheumatoid Arthritis was just aches and pains – until I got it myself – totally out of the blue -aged 39.
It is agonising, and doctors do not know what causes it or what to do about it. It would be great if something could be found without horrendous side effects. I take nothing for mine and I keep working, but my life is a tenth of what it was.

I really hope this is the drug that many Arthritis sufferers have waited for. My Mum suffers from chronic RA and it can be heartbreaking to see her in so much pain. She’s only 57 and has suffered since she was 21.
I still feel that there are people that dismiss arthritis as something ‘old people’ suffer from but nothing could be further from the truth.
She’s tried many different drugs over the years and unfortunately the only one that really gave her a new lease of life and a life free from pain was damaging her liver, so now she’s self injecting a relatively new drug once a week but still has days when she struggles to walk or even make a cup of tea. Her hands, feet and knees look like a 90 year olds, I’d do anything to take her pain away.
I pray with all my heart that this drug is the wonder drug that sufferers have waited too long for.

Google these, cayenne, ground chilli, these two can help cut out the pain of Arthritis, this I knoiw as I’m on cayenne and the pain has gone from my righthand knuckle joints this year, as they give me a real pain during hand olive picking and take about six weeks to get over it.
Also if you get on earthclinic they say about high doses of glucosamine is a cure for arthritis.
Ok I dont know how this works with any drugs people are on, or how this works with RA, but sometimes its the simple things that work the best.
Good Luck

My Mother suffers badly from RA.Her hands were badly swollen and I rubbed on some Penang Nutmeg oil.We had recently been to Malaysia and bought some after being assured it helped all sorts of conditions.We didn’t believe it but were on holiday so bought it.It worked!Next morning all swelling was down and her hands felt much better.She now uses it every day and has had no swelling for 2 months.You can buy Nutmeg oil on the net but it is not Penang Nutmeg oil.We are aiming to return next year and will buy loads!
By the way,I then used it on my neck and it worked for me too.

Works on mice ! Great !

There are already drugs available that work in this way such as Humira which my mother took for RA. It acts by suppressing the immune system and despite being screened for latent TB before starting the drug she was dead within 3 months from full blown tuberculosis.

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Article source: http://www.dailymail.co.uk/health/article-2110490/Drug-treat-arthritis-stopping-immune-attacking-joints.html?ITO=1490

By
Jenny Hope

Last updated at 10:29 AM on 22nd February 2012

A drug that could ease the agony of thousands of rheumatoid arthritis sufferers has been given the go-ahead for many more NHS patients in England and Wales.

RoActemra, which is the first innovation in the field for ten years, is being recommended for patients who have failed on standard treatments.

It is the first time RoActemra has been approved for NHS patients in England and Wales with moderate to severe rheumatoid arthritis who are at an early stage in the disease.

Hope: The NHS given go-ahead to prescribe RoActemra which eases the agony of rheumatoid arthritis

Hope: The NHS given go-ahead to prescribe RoActemra which eases the agony of rheumatoid arthritis

The drug has been available for early use in Scotland for two years.

At present in England and Wales it is used by only 1,200 patients at later stages of the disease. The decision by the Government’s rationing body, the National Institute for Health and Clinical Excellence (Nice), means up to 40,000 more patients will be eligible.

The £9,000 annual cost of RoActemra, also known as tocilizumab, is the same as other advanced ‘biologic’ drugs already being used, but a discount scheme has been agreed with manufacturers Roche.

Trial data shows almost half of patients on RoActemra are in remission – with virtually no symptoms – after a year compared with 8 per cent on a commonly used drug called methotrexate.

The rate of remission is almost six times higher than on methotrexate alone.

Trial data shows almost half of patients on RoActemra are in remission ¿ with virtually no symptoms

Trial data shows almost half of patients on RoActemra are in remission ¿ with virtually no symptoms

The new drug is a laboratory-manufactured antibody that blocks the activity of interleukin 6 (IL-6), an important immune system signalling molecule  that underpins many inflammatory processes.

Because RoActemra works in a completely different way to existing drugs it is likely to be effective in some patients where the other drugs don’t work or have stopped working.

John Isaacs, professor of clinical rheumatology at Newcastle University, says it vital sufferers have options

John Isaacs, professor of clinical rheumatology at Newcastle University, says it vital sufferers have options

John Isaacs, professor of clinical rheumatology at Newcastle University, said: ‘Rheumatoid arthritis is an unrelenting disease and it is vital that patients have options available to them when they are no longer responding to, or can no longer tolerate, their current treatment.’

The disease occurs when the body’s immune system attacks the joints causing pain and swelling, most commonly in the hands, wrists and feet.

NHS figures suggest it affects 400,000 people in England and Wales, striking three times more women than men. It is most common between the ages of 40 and 70. Half of victims are unable to work through disability within ten years.

Professor Isaacs said it was vital to treat people as early as possible with the most effective drugs. He added: ‘We have evidence that if you can stop the disease early, you can change the way it progresses for the rest of the patient’s life.

‘This is particularly important when it strikes at a young age – women can be affected in their 40s and 50s but it can start in the 20s and younger.’

Ailsa Bosworth, chief executive of the National Rheumatoid Arthritis Society, said: ‘We are delighted with Nice’s decision, as there are so many patients with rheumatoid arthritis in need of tighter disease management.

‘This decision is most welcome as it is vital that patients have effective options available as soon as one treatment approach fails.’

Professor Carole Longson, director of the health technology evaluation centre at Nice, said: ‘Rheumatoid arthritis can have a huge impact on quality of life and for many it’s a disabling condition, so we’re pleased to recommend tocilizumab at an additional stage in treating the condition.’

The drug was also approved in December for children with  systemic juvenile arthritis, a severe inflammatory disease that can affect those as young as 18 months.

Around 2,500 children in Britain are living with the disease, which can persist into adulthood and cause significant disability.

 

Here’s what other readers have said. Why not add your thoughts,
or debate this issue live on our message boards.

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i agree with former young R.A sufferer diet does play apart in R.A process. The immune system is 80% in GUT and if incorrect antibodies are produced down there then it spreads to the joints.
God help R.A sufferers wish doctors would understand this!

my mum died at 64 she had RA was on methotrexate. she had to go into hospital for a blood transfusion was in for 3 weeks came out on the tues back in on sunday and died Monday. hope this drug works what a horrible painful disease heartbreaking to see someone who suffers through it.

my mum had RA suffered terribly for a couple of years before dying at 64 she was on methotrexate terrible drug. anything that can give hope to sufferers is fabulous news hope this is going to make life a lot easier for a lot of people good luck

The article says that RoActemra works in a completely different way to existing drugs. I hope it is different to Adalimumab (Humira) which is a similar drug also prescribed for RA. It was given to my mother and within 3 months of starting it she died from Tuberculosis as the drug suppressed her immune system allowing the TB to flare up. Before starting Humira she was screened for latent TB which wasn’t found so she was allowed to take it. The manufacturers Abbott Laboratories showed great interest while she was alive, calling almost every day to check her progress. When we told them she was in hospital with TB the calls stopped they didn’t want to know any more.

This is fantastic news, but to those fellow sufferers out there who are also in their 20s, I had all the symptoms of RA, and I did a food exclusion diet where I found out I was allergic to wheat. Now I no longer get any symptoms, so long as I never eat anything with wheat flour in it (bread, pasta, etc). This also runs among the women in my family. I wish more doctors would realise the link between food allergies and autoimmune disorders. My doctor thought I was mad. But he was wrong!

Methotrexate is a horrible drug but what are the side effects of RoActemra are they as bad?

Excellent news – RA is the most horrendous thing I have ever known and I would be delighted to see some improvement.
I doubt it will be rolled out quickly, but will be ringing my RA nurse today to say I am interested in it.

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Article source: http://www.dailymail.co.uk/health/article-2104499/NHS-given-ahead-prescribe-new-drug-eases-agony-rheumatoid-arthritis.html?ITO=1490

By
Dina Behrman

Last updated at 9:45 PM on 18th February 2012

Laura Wright was just 15 when she won the BBC Radio 2 Chorister of the Year competition in 2005. For the soprano, now 21, the moment marked what she hoped would be the end of the ill-health that had threatened to rob her of both her singing ambitions – and her mobility.

When she was nine, Laura was told she might never walk again after contracting septic arthritis. ‘It was quite sudden,’ recalls the singer, who ran in the London Marathon last year and whose solo debut The Last Rose was No 1 in the classical charts for five weeks last year.

‘We were on holiday and I went for a jog with my dad and afterwards my right knee started to hurt. It got more and more painful, so my mum and dad took me to hospital.

Laura Wright has said that going through the health scare has made her more determined than ever

Laura Wright has said that going through the health scare has made her more determined than ever

‘I was examined and scanned and they did all sorts of blood tests but could find nothing wrong, so I was sent home and told it would probably get better.’

However, the pain got worse. Within a month, Laura was confined to a wheelchair. She was admitted to hospital, where she remained for six months as doctors tried everything they could to get her back on her feet.

‘It turned out I had an infection in my knee,’ she says. ‘My leg felt much more comfortable bent rather than straight, but the doctors straightened it out and put it in a cast.

‘That’s when the infection began to spread through my entire body and I got very ill. At that point they were able to diagnose me with septic arthritis.’

Septic arthritis is an infection in a joint. Many different types of bacteria can cause it, but one called staphylococcus aureus is the most common culprit.

Bacteria can get to a joint via the bloodstream, from an infection in another part of the body, via an injury to the joint itself, or during surgery. Those suffering other types of arthritis are at higher risk, as are those with a compromised immune system – such as patients on chemotherapy or the elderly.

The knee is the site of infection in more than half of septic arthritis cases, and the hip is affected in about one in five cases. If the infection is treated promptly, there is a good chance of complete cure with no long-term problems. But if there is a delay in treatment, the infection can quickly destroy the joint, leading to long-term pain and disability.

Laura during her chorister days

Laura during her chorister days

In some cases, the infection becomes severe and leads to  potentially fatal blood poisoning – septicaemia.

Laura says: ‘I was in too much pain to walk and I was so weak I couldn’t eat anything. I was so young that they struggled to get fluids into my veins, and in the end they had to put the tubes in my neck. So then I was bedbound for quite some time. I had to have a nurse take me to the toilet and I had to have someone dress me. I couldn’t do anything myself.

‘Things got so bad that the doctors were worried I would never walk again. In fact, at one point they told my parents, “You should spend as much time with Laura as you can.”

After she was diagnosed, doctors tried different methods to treat her, including performing several operations to drain the fluid from her knee and prescribing various antibiotics to kill off the infection.

Eventually she recovered enough to leave hospital, but the road to recovery was a slow one.

‘When I went back to school I was in a wheelchair and then on crutches, hobbling around like a 90-year-old – it was utterly frustrating,’ she says. ‘But I know I was very lucky.

‘And I know that going through all that has definitely given me every ounce of determination and drive to embrace every opportunity I get.’

As soon as she was off the crutches, Laura threw herself into sport and was soon playing hockey for East of England. She also represented her county in netball. ‘I was super-keen because I had this opportunity I might not have had,’ she explains.

Today her right leg is weaker than her left, and it sometimes aches, but Laura isn’t letting it hold her back. ‘It’s a small price to pay so to me it doesn’t matter,’ she says.

These days she eats healthily and is conscious of managing stress levels. She goes to the gym four or five times a week and recently completed the Actimel Pedal to Paris, cycling an impressive 300 miles in aid of the Royal British Legion.

Consultant orthopaedic surgeon Elliot Sorene says: ‘The condition eats away at the cartilage and destroys the joint. In a child of that age, it could cause deformity or even lead to limb replacement, so Laura is lucky.

‘Such a condition may well lead to problems with arthritis in the future – she will probably have suffered some cartilage loss so the fact that she’s super-fit will help prevent this.’

Laura says: ‘Going through my health difficulties when I was younger was something that motivated me to do the bike ride. One of organisers told me the other day they were planning a trek across the Pyrenees – maybe that’ll be my next challenge.’

lLaura Wright’s The Last Rose is available on Decca Records

 

Article source: http://www.dailymail.co.uk/health/article-2103125/Voice-angel-knees-pensioner-Soprano-Laura-Wright-speaks-battle-beat-septic-arthritis.html?ITO=1490

By
Fiona Macrae Science Correspondent

Last updated at 12:01 AM on 17th February 2012

Scientists have invented an electronic chip that could put an end to painful daily injections for osteoporosis sufferers.

The device, slipped under the skin, releases daily doses of the bone-building drug teriparatide.

In trials on elderly women, it worked just as well as regular injections of the medicine. 


Size comparison: The MicroCHIPS wireless drug-delivery device, right, which is placed in the body, is pictured next to a conventional computer memory stick

Size comparison: The MicroCHIPS wireless drug-delivery device, right, which is placed in the body, is pictured next to a conventional computer memory stick

Crucially, many said the device – the first of its kind – was so comfortable that they often forgot it was there.

The chip can be adapted to dispense
other medicines and it is hoped it will be popular with those who
dislike injecting themselves, or find it difficult to do so due to
arthritis. It could also ensure better treatment. 

Although drugs such as teriparatide –
also known as Forsteo – work well, the lack of any outward sign that
they are improving health means that up to three-quarters of
osteoporosis patients stop taking them.


Microchips graphic 1

With the condition affecting 3million
Britons, the innovation could have a dramatic impact on quality of life,
the American Association for the Advancement of Science’s annual
conference in Vancouver, Canada, heard.

The device’s co-inventor, Robert
Langer, one of the world’s top scientists, said: ‘Patients are freed
from the daily reminder, or burden, of disease, by eliminating the need
for regular injections.’  

The chip contains a series of tiny
wells, each packed with a daily dose of teriparatide. The drug is so
potent, that a day’s supply is no bigger than a pin head. The wells,
which are sealed with an ultra-fine layer of titanium and platinum, pop
open either on a programmed schedule or in response to a wireless
signal.


Microchips graphic 2

Clear potential: MicroCHIPS president Robert Farra says the wireless device is fully programmable and can deliver the right drugs dosage even if patients forget

Clear potential: MicroCHIPS president Robert Farra says the wireless device is fully programmable and can deliver the right drugs dosage even if patients forget

This rapidly releases the drug into the bloodstream.

The chip is housed in a casing which
also contains a battery, as well as the electronics needed for a
wireless signal and the control of drug release. The whole device is
about two inches in height.

The chip, which is about five years
from the market, takes 30 minutes to insert into the abdomen, just below
the skin. The operation is done under local anaesthetic and patients
can walk home afterwards.

Results of a trial on eight women,
published in the journal Science Translational Medicine, show chips
loaded with 20 days’ supply of treatment worked well in all but one
case. Scientists from MicroCHIPS, the U.S. firm commercialising the
device, are working on a chip that carries and dispenses hundreds of
doses.

Other illnesses that could be treated in this way include diabetes, cancer, multiple sclerosis and heart disease.

The inclusion of wireless technology would allow doctors to remotely alter the amount of drug dispensed as necessary.

Professor Langer, whose other
achievements range from growing an ear on the back of a mouse to
creating a spray that keeps frizzy hair at bay, said: ‘You could
literally have a pharmacy on a chip.’

Julia Thomson, of the National
Osteoporosis Society, said that swapping daily jabs for an implant would
make it easier for patients to take their drug.

Here’s what other readers have said. Why not add your thoughts,
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Due to side effects of the tablets I asked for the injection and my GP says its expensive at £5,000 and suggested I try the other medication first. So I doubt for one minute this treatment will only be for those who can afford to have it done privately.

Could not these patients be given Aclasta for osteoporosis? It involves being given a once-per-year 10-minute infusion.

Once again it “will be available within 5 years”….. It’s always “5 years”. Just for once could we have a report of something available NOW. Meanwhile, I predict that this will sink without a trace.

My wife has needle phobia and she said that this looks worse than the needle.

Too easy to mock when you are healthy. Just nice to know there is still money for research to give chronic sufferers some hope.

Have you seen the size of the needle they use to put that thing in you????????

Yh, and who is willing to have that massive thing put in them?

This comes with a secret side serving of Radiation and chemotherapy with that?

The views expressed in the contents above are those of our users and do not necessarily reflect the views of MailOnline.

Article source: http://www.dailymail.co.uk/health/article-2102210/Chip-end-daily-jabs-osteoporosis.html?ITO=1490

By
Hilary Freeman

Last updated at 10:08 PM on 4th February 2012


Tiffany Robertson says she can do everything, including morris dancing

Tiffany Robertson says she can do everything, including morris dancing

Children suffering the agony of juvenile arthritis – which can leave many wheelchair-bound and result in permanent deformity – have been offered hope from a new drug therapy.

The National Institute for Health and Clinical Excellence, the body that provides prescribing guidelines, has approved RoActemra (tocilizumab) to treat systemic juvenile idiopathic arthritis (sJIA). Currently incurable, sJIA is the most severe type of juvenile arthritis and affects about 2,500 under-16s in the UK.

It is an extremely debilitating inflammatory condition causing extreme joint pain, a distinctive salmon-coloured skin rash and a constant high fever. It can also lead to problems with the spleen, liver and heart that can be life-threatening.

Dr Eileen Baildam, a paediatric rheumatologist at Alder Hey Children’s Hospital in Liverpool, says nobody knows the causes but it is thought to be an autoimmune condition, with a genetic component. ‘About a third of patients get better spontaneously, but two-thirds will continue to have serious flare-ups,’ she says.

One patient to have benefited already is 12-year-old Tiffany Robertson, who was five when she developed the condition. It left her in agony and bedridden for months. Her mother Kate, 34, from Southport, Merseyside, recalls: ‘The joints all over her body would swell up and stiffen and it could happen in one area or in several places at once: her hips, wrists, neck, ankles, fingers and toes.

RoActemra, previously used to treat adult
rheumatoid arthritis, works by blocking an immune system messenger
called IL-6, which causes fever and inflammation in joints and organs 

‘She couldn’t get herself to the bathroom and if I touched her, she would scream. At some points she needed a wheelchair. She was put on steroids, with terrible side effects. By the time she was seven, she was so bloated that she was wearing clothes for 11-year-olds. People stared at her, which made her very self-conscious. She missed so much school they put a bed for her in the classroom, so she could at least be around other children.’

Tiffany tried various medications but none worked for long. Until now, the commonly used treatments for sJIA were anti-inflammatory drugs – ibuprofen or corticosteroids and methotrexate – which often do not slow the progression of the disease.

RoActemra, previously used to treat adult rheumatoid arthritis, works by blocking an immune system messenger called IL-6, which causes fever and inflammation in joints and organs.

IL-6 is meant to protect the body against infection but malfunctions and attacks the body. The more damage that occurs, the more the immune system’s white cells produce IL-6 to fight the unknown invader.

The new drug will bring relief to nine in ten young patients

The new drug will bring relief to nine in ten young patients

RoActemra was licensed for use following a five-year trial. Dr Baildam says the results were astounding. ‘After a year, two-thirds of patients had a 90 per cent improvement in their symptoms, which is extraordinary – three times as good as we had expected. For a lot of patients it switches off the condition. And it’s well tolerated with virtually no side effects. It gives thousands of children hope of restoring normality to day-to-day life.’

Eighteen months ago, just as she was about to start secondary school, Tiffany was allowed to try RoActemra, which is administered in hospital every two weeks by drip. ‘We were desperate,’ says Kate. ‘We didn’t want Tiffany to go on the trial because we were worried she would get a placebo and deteriorate even more, so she was prescribed the drug on compassionate grounds. After nine months we started to notice a difference and now you wouldn’t know she has sJIA.

‘She gets the odd niggle but she’s able to go to school every day and she even does morris dancing, travelling all over the North West. She’s a lot happier. The drug has made a huge difference to all our lives.’

Tiffany says: ‘I used to be very poorly, on and off, and miss school and going out with my friends, but now I can do everything I want to do, just like everybody else.

‘I am very thankful to my doctors and nurses for getting me the new medicine and looking after me.’

 

Article source: http://www.dailymail.co.uk/health/article-2096448/Jab-ends-agony-childhood-arthritis-New-NHS-treatment-brings-relief-young-patients.html?ITO=1490

By
Alice Smellie

Last updated at 10:03 PM on 21st January 2012


Steve Hall, wearing his shoes, while carrying his son Matthew

Steve Hall, wearing his shoes, while carrying his son Matthew

They may look more like something a trendy teenager would wear, but a pair of custom-made, high-top trainers can offer patients relief from the crippling pain of knee arthritis.

There is no cure for the condition which accounts for one million GP appointments each year. Treatment traditionally involves painkillers, a knee replacement or other surgery. About 80,000 of these operations are carried out in the UK each year.

Osteoarthritis is damage to cartilage, the smooth surface that lines bones and allows joints to move easily. Why it happens is not fully understood but genetic predisposition and natural wear and tear are thought to  play a role. As the disease progresses, bony growths develop around the edge of the joints, causing pain and inflammation.

The trainers, known as AposTherapy, were
developed in Israel in 2004 and results of a pilot trial on 1,300
British patients were released last year. During the trial, 67 per cent
were able to reduce their need for painkillers, with 40 per cent no
longer needing any at all.

Physiotherapist Ed Butler explains: ‘The
trainers correct the way you walk, which takes pressure off the knee,
alleviating pain. You are engaging your core muscles and realigning the
body.’ As osteoarthritis progresses, the knee joint becomes more
unstable, and the muscles around it begin to be affected to compensate.

‘Sufferers often limp due to the hamstring muscles having tensed. As the condition takes hold, and before pain becomes too acute, the brain reacts and forces muscles to work in the wrong way,’ says Mr Butler.

Attached to the soles of the trainers – one at the front and one at the heel – are circular and convex Pertupods made of a rubber compound, which can be either soft or hard. ‘If someone feels a lot of pain when they put their feet down, we’d give them a softer one to lessen the impact,’ says Mr Butler.

‘For the more mobile, the harder ones make them more aware of how they are walking. The soles are like a wobble-board, forcing the wearer to balance and correct their posture.’

The Pertupods can be altered according to the patient’s therapeutic needs, determined by a physiotherapy assessment. The shoes are worn for everyday activities and no further exercises are needed.

‘People may wear them for a few hours a day initially,’ says Mr Butler. ‘As their gait is corrected, we encourage them to rely on them less.’

Three months after wearing the trainers he was nearly pain-free

Three months after wearing the trainers he was nearly pain-free

One satisfied patient is Steve Hall,  49, a retired detective chief inspector who lives in Surrey with his wife Sarah, 44, a childminder, and their eight-year-old son Matthew.

‘I had a motorcycle accident at the age of 20 and broke my left tibia and fibula. In 2003 my knee started to swell up,’ he says.

Tests revealed he was suffering from osteoarthritis. ‘I was told I had the knee of a 70-year-old,’ he adds.

In 2004, Mr Hall underwent a tibial osteotomy, a surgical procedure that realigns the leg. ‘It improved things,’ he says. ‘But I was still in pain and I would have needed a knee replacement at some point.’

Three years ago he came across AposTherapy and was attracted to it because it was drug-free. Three months later, after wearing the trainers daily, he was almost pain-free.

‘I would put them on in the morning, go to work and wear them all day,’ he says. The result is that he now doesn’t need a knee replacement.

Independent clinical experts are optimistic about the treatment.

‘I have referred patients,’ says Dr Hasan Tahir, consultant physician in acute medicine and rheumatology at Whipps Cross University Hospital in London.

‘Addressing posture is an important part of the management of osteoarthritis.

‘But this is only part of the pro–cess. Losing weight is the first step and painkillers or steroid injections may still be needed.’

Three years later, Steve wears the trainers for a couple of hours a day for four or five days a week.

‘The best thing is that I can now referee my son’s football team,’ he says.

lFrom £2,100, apostherapy.co.uk. Treatment free for Bupa patients.

 

Article source: http://www.dailymail.co.uk/health/article-2089947/The-wobble-board-trainers-beat-pain-knee-arthritis.html?ITO=1490

  • Osteoarthritis usually develops in people aged 50 plus
  • Abnormally short DNA sequences linked to painful joint disease

By
Sadie Whitelocks

Last updated at 1:33 PM on 16th January 2012

Scientists believe they are closer to pinpointing the exact cause of osteoarthritis, offering the hope of more effective treatment.

A team from the University of Southern Denmark found shortened ends of chromosomes, were linked to the onset of the degenerative disease.

Abnormally short chromosome caps, called telomeres, were seen in cells from damaged knee joints and those near the areas of severe damage were ‘ultra-short’.

Scientists believe they are closer to finding the exact cause of osteoarthritis

Scientists believe they are closer to finding the exact cause of osteoarthritis

These latest findings show that that these lengths of DNA play an integral role in the development of the condition which leads to stiffness and pain in different joints – most commonly in the hands.

It is hoped that this will prompt more effective treatment for osteoarthritis (OA), the most common
form of arthritis, for which there is no cure.

Commenting on the findings lead researcher Dr Maria Harbo said: ‘We see both a reduced mean
telomere length and an increase in the number of cells with ultra-short
telomeres associated with increased severity of OA.’

Researchers studied telomere length in cells taken from the knees of three women with osteoarthritis.

They found that average telomere
length was shortened in the affected joints, and telomeres became
shorter near the areas of worst damage.

Biological ageing causes the gradual shortening of telomeres – DNA sequences which protect the ends of chromosomes – but a host of other factors can make them shorten
over time, including damage caused by oxygen
free radicals (oxidative stress).

Oxygen free radicals are the unstable molecules produced as a by-product of normal bodily processes, as well as external factors, such as tobacco, alcohol, and sunlight.

The shortening of telomeres is linked to reduced lifespan, heart disease and osteoarthritis and previous research has shown that preserving the length of these chromosomal ‘bookends’ can increase life expectancy.

People with very long life
spans have also been shown to possess longer telomeres.

On the other hand there is evidence that out-of-control telomere recovery may be linked to cancer.

The findings are published in the online journal Arthritis Research Therapy.

Each year more than 140,000 hip and knee replacement operations are performed on the NHS in England and Wales.

Osteoarthritis usually develops in people over 50 years of age and can be accelerated by previous injury or repetitive stress to joints.

There is no cure for the disease but there is a range of treatments to relieve discomfort.

Article source: http://www.dailymail.co.uk/health/article-2087258/DNA-breakthrough-gives-vital-clue-cause-osteoarthritis.html?ITO=1490

Rheumatoid arthritis (RA) could be included in England’s Quality Outcome Framework (QOF). Arthritis Care has long campaigned for arthritis to be covered by the QOF to ensure the condition is prioritised and those living with it get the best outcomes from their healthcare service.

There are 20 potential new QOF indicators across nine areas currently being consulted on – RA is one of the areas being proposed. NICE is now consulting on whether to include RA and the five indicators they have chosen for the condition.

‘This is potentially great news for those living with RA in England,’ said Federico Moscogiuri, head of policy and campaigns at Arthritis Care. ‘Arthritis Care will be responding to the consultation to ensure we push for the most appropriate indicators to be included.’

Dr Fergus Macbeth, director of the Centre for Clinical Practice at NICE, said: ‘This consultation on potential new indicators is an integral part of NICE’s process for QOF. The final menu of indicators, to be published on the NICE website in August, will support healthcare professionals to deliver good quality patient care, based on the best available evidence.’

Introduced in 2004, the QOF is a voluntary incentive scheme for GP practices in England, rewarding them for how well they care for patients. Arthritis Care continues to campaign for osteoarthritis to be included in the QOF.

Article source: http://www.arthritiscare.org.uk/NewsRoom/Latestnewsstories/rheumatoid-arthritis-in-quality-outcome-framework-consultation

In a statement issued by the Board of Trustees on 22 September, the chair of Arthritis Care, Rosemary Blair, has announced that chief executive, Neil Betteridge, is moving on to pursue new career options.

‘Neil has brought enormous strengths to Arthritis Care over 11 years, for the past seven as chief executive. He has succeeded in raising the needs of people with arthritis up the political agenda at national and local levels and has built strong relationships with leading health professionals.

‘He has also provided great personal and professional knowledge and expertise to Arthritis Care. Under his leadership, Arthritis Care has become a leading and respected voice of people with arthritis and he leaves a legacy of policy change and service delivery that we will continue to build on. We will be very sad to see him go.

‘The Board join with me in expressing our warmest thanks to Neil and in wishing him every success in the future.

‘The Board will shortly start the search for a new chief executive to lead the organisation at a time of new challenges facing so many of us in the voluntary sector.’

Commenting on his move, Neil Betteridge said:

‘Having grown up with arthritis as a child, being chief executive of Arthritis Care has been a dream come true for me. But I believe that now is the right time for me to be seeking new opportunities at a personal level. It also means Arthritis Care can appoint a successor who will have time to develop and deliver the next long term strategy, as we approach the final year of the current plan.

‘I will miss the many people who make Arthritis Care unique. Our members, volunteers and other supporters are passionate about their work for Arthritis Care and, supported by our dedicated staff around the UK, they make a huge difference to people’s lives on a daily basis.

‘I wish my successor well and if I can offer any support to him or her, I would be happy to do so.’

Arthritis Care contacts

Alba Lewis, director of fundraising and communications AlbaL@arthritiscare.org.uk
Clare Mills, executive assistant  ClareM@arthritiscare.org.uk Tel: 020 7380 6558

Article source: http://www.arthritiscare.org.uk/NewsRoom/Latestnewsstories/arthritis-care-announces-departure-of-chief-executive

Arthritis Care has announced the appointment of Susie Parsons as interim chief executive. She takes over from Neil Betteridge, who resigned in September.

Susie Parsons said ‘Like all voluntary organisations, Arthritis Care is operating in a difficult funding climate and I am looking forward to working with the Trustees and staff to secure a sustainable future for the services and campaigns which are so tremendously important to people living with arthritis.’

Having spent all her working life in the public and voluntary sectors, including as chief executive of the Commission for Racial Equality, London Lighthouse and the National Campaign for Learning, Susie set up an interim management and consultancy business in 2005, specialising both in turning round organisations in difficulty and supporting successful ones to become even better.  She has served as Interim chief executive of the Refugee Arrivals Project, the Barrow Cadbury Trust and the Novas Scarman Group.

Article source: http://www.arthritiscare.org.uk/NewsRoom/Statementsandpressreleases/UXpW